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Predicting irregularities in arrival times for transit buses with recurrent neural networks using GPS coordinates and weather data

Intelligent transportation systems (ITS) play an important role in the quality of life of citizens in any metropolitan city. Despite various policies and strategies incorporated to increase the reliability and quality of service, public …

Behavioral patterns and associations with glucose control during 12-week randomized free-living clinical trial of day and night hybrid closed-loop insulin delivery in adults with type 1 diabetes

**Objectives:** We evaluated patterns of meal intake, insulin bolus delivery, and fingerstick glucose measurements during hybrid closed-loop and sensor-augmented pump (SAP) therapy, including associations with glucose control. **Methods:** Data were …

Comparison of two continuous glucose monitoring systems, Dexcom G4 Platinum and Medtronic Paradigm Veo Enlite System, at rest and during exercise

**Background**: Despite technological advances, the accuracy of continuous glucose monitoring (CGM) systems may not always be satisfactory with rapidly changing glucose levels, as is notable during exercise. We compare the performance of two current …

Efficacy of single-hormone and dual-hormone artificial pancreas during continuous and interval exercise in adult patients with type 1 diabetes: randomised controlled crossover trial

**Aims/hypothesis**: The aim of this study was to assess whether the dual-hormone (insulin and glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (insulin alone) artificial pancreas during two types of exercise. …

Modeling glucagon action in patients with type 1 diabetes

The dual-hormone artificial pancreas is an emerging technology to treat type 1 diabetes (T1D). It consists of a glucose sensor, infusion pumps, and a dosing algorithm that directs hormonal delivery. Preclinical optimization of dosing algorithms using …

Enhancing glucose sensor models: modeling the drop-outs

**Background:** Computer simulation environments have been used in the development of many artificial pancreas systems. A glucose sensor model is an essential part of these environments, and different models have been proposed. However, not one of …

Practical Approach to Physical-Chemical Acid-Base Management: Stewart at the Bedside

The late Peter Stewart developed an approach to the analysis of acid-base disturbances in biological systems based on basic physical-chemical principles. His key argument was that the traditional carbon dioxide/bicarbonate analysis with just the use …